PleoPharma, Inc. was founded in 2019 by two physicians, Ginger Constantine and Jay Constantine, one of whom worked to develop new medications and the other as a practicing clinician.
 
The idea for Pleopharma was spawned when the founders observed several individuals within a short period of time who were in obvious distress and severe discomfort when they were trying to discontinue cannabis use.
 
Like many people at the time, the founders were not aware that a withdrawal syndrome for cannabis existed. They were surprised at the severity of the withdrawal symptoms and the impediment this posed to discontinuing cannabis.
 
In an effort to help, the founders began researching the topic and learned that there was an extensive scientific literature regarding both Cannabis Use Disorder (CUD) and Cannabis Withdrawal Syndrome (CWS). Many potential treatments had been studied; unfortunately, none proved to be effective.  
 
In the face of this growing crisis, they set out to find a safe and effective treatment to address this unmet need and therefore formed PleoPharma, Inc.